Table 2.

Significantly Enriched GO Terms, KEGG, and RCTM Pathways of DEGs.

Category	Term	Description	Count in gene set	FDR
BP term	GO:0043062	Extracellular structure organization	16	4.18E−12
BP term	GO:0030198	Extracellular matrix organization	14	1.48E−10
BP term	GO:0030199	Collagen fibril organization	8	5.17E−10
BP term	GO:0071229	Cellular response to acid chemical	7	8.90E−04
BP term	GO:0001568	Blood vessel development	9	2.90E−03
CC term	GO:0005583	Fibrillar collagen trimer	6	1.18E−09
CC term	GO:0044420	Extracellular matrix component	7	4.25E−08
CC term	GO:0044421	Extracellular region part	18	1.41E−06
CC term	GO:0031012	Extracellular matrix	9	5.15E−06
CC term	GO:0062023	Collagen-containing extracellular matrix	7	7.99E−06
MF term	GO:0048407	Platelet-derived growth factor binding	4	2.78E−05
MF term	GO:0004497	Monooxygenase activity	4	7.50E−03
MF term	GO:0005201	Extracellular matrix structural constituent	4	7.50E−03
MF term	GO:0016404	15-Hydroxyprostaglandin dehydrogenase (NAD+) activity	2	7.50E−03
MF term	GO:0043167	Ion binding	32	7.50E−03
KEGG pathway	hsa04974	Protein digestion and absorption	5	5.80E−04
RCTM pathway	HSA-1474244	Extracellular matrix organization	12	1.59E−08
RCTM pathway	HSA-3000178	ECM proteoglycans	8	1.59E−08
RCTM pathway	HSA-3000170	Syndecan interactions	6	3.17E−08
RCTM pathway	HSA-1442490	Collagen degradation	7	8.18E−08
RCTM pathway	HSA-216083	Integrin cell surface interactions	7	3.53E−07

BP: biological process; CC: cellular component; DEGs: differentially expressed genes; GO: gene ontology; KEGG: Kyoto encyclopedia of genes and genomes; MF: molecular function; RCTM: Reactome.