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. 2020 Oct 21;29:0963689720968495. doi: 10.1177/0963689720968495

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Schematic diagram of intra-articular injection of exosomes derived from MSC that act on articular chondrocytes, synoviocytes, osteoblasts, and maintain articular microenvironment homeostasis. The pathological changes of OA involved in cartilage degeneration, synovitis, and subchondral bone deterioration. Exosomes derived from MSC alter the component contents of synovial fluid. Red dots: exosomes in synovial fluid of OA; green dots: exosomes derived from MSC; yellow dots: exosomes of altered composition in OA after intra-articular injection of exosomes derived from MSC; down arrows: downregulation; and up arrows: upregulation. MSC: mesenchymal stem cell; OA: osteoarthritis.