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. 2020 Nov 10;29:0963689720971245. doi: 10.1177/0963689720971245

Figure 2.

Figure 2.

Local pretreatment of islets with liraglutide is more effective for lowering blood glucose levels in STZ-diabetic mice transplanted with islets. STZ-induced diabetic mice were randomly divided into five groups: sham-operated group (n = 6, Sham), 300 islets-transplanted group (n = 6, I300), 200 islets-transplanted group (n = 8, I200), 200 islets with local liraglutide (n = 8, I200-local), and 200 islets with systemic liraglutide (n = 8, I200-systemic). The normalized mice underwent nephrectomy 35 days after transplantation. Age-matched and sex-matched C57BL/6 J mice were used as a nondiabetic control group (n = 5, control). (A) Nonfasting blood glucose levels were monitored for 40 days. (B) The AUC for blood glucose levels was measured up to 35 days prior to nephrectomy. (C) The glucose tolerance test was performed 28 days after islet transplantation. (D) AUC for blood glucose levels was measured during glucose tolerance testing. The data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.005 versus control; # P < 0.05, ## P < 0.01 versus sham; §§ P < 0.01 versus I300; †† P < 0.01 versus I200. AUC: area under the curve; STZ: streptozotocin.