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. 2020 Oct 19;29:0963689720966265. doi: 10.1177/0963689720966265

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — ICS reduced transfusion-related immune modulation of monocytes in a model of bacterial infection. Monocyte intracellular cytokine production and expression of surface activation and adhesion molecules following exposure to standard allogenic blood or autologous ICS. X axis: in vitro “transfusion” conditions, preoperative sample (Pre-Op, closed black circles), preoperative sample + ABO-compatible allogeneic blood (Pre-Op + ABO, closed purple squares), and preoperative sample + their own cell salvage blood (Pre-Op + ICS, closed green diamonds). Y axis: median fluorescent intensity of indicated cytokine or surface marker in gated monocytes (CD14⁺). Analysis of variance indicated by bar and P-value with Tukey’s post-test indicated by *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

HLA-DR: human leukocyte antigen DR phenotype; ICS: intraoperative cell salvage; IL: interleukin; MCP-1: monocyte chemoattractant protein-1; MIP-1α: macrophage inflammatory protein-1 alfa; TNF-α: tumor necrosis factor alfa.