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. 2020 Sep 3;30(12):1127–1135. doi: 10.1038/s41422-020-00404-6

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© Center for Excellence in Molecular Cell Science, CAS 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Overall view of all the phospholipids bound in the center, lower-side and outer-side cavities of MlaFEDB. The lipids bound in the cavity are circled in blue, orange and green, respectively. Zoomed-in views of the circled regions are shown in b–d, and the colored boxes in e–l correspond to the zoom-ins shown in b–d. b–d Zoom-in views of the phospholipid bound in the center, lower-side and outer-side cavities in MlaFEDB. Cryo-EM densities are shown superimposed with the atomic model of phospholipids. e Cross-sectional view of the electrostatic surface of the central cavity. f–h Zoomed-in view of detailed interactions between the phospholipids with MlaD and MlaE. Positively charged and negative charged regions are shown in blue and red, respectively. Phospholipids are shown as green sticks. MlaD and MlaE are shown in light blue and wheat, respectively. i Cross-sectional view of the electrostatic surface of the lower-side cavity. j Zoomed-in view of detailed interactions between the phospholipids and TMs of MlaD (gray) and MlaE (wheat). k Cross-sectional view of the electrostatic surface of the outer-side cavity. l Zoomed-in view of detailed interactions between the phospholipids with the MCE domain of MlaD (gray) and TM4 of MlaE (wheat). m Complementation of MlaFEDCB mutants in MlaFEDCB deletion strain.