Table 1.

Study characteristics for included studies.

Study	Setting					Methods		Population			Intervention
	Year of study publication	Country	Setting	Year(s) of data collection	Scale	Design	Data Source	N (Study sample)	% White	% Female	Disease Area	Counseling related to cascade testing	Cascade testing primarily mediated by	Provision of resources related to cascade testing	MMAT Score
Benson13	2016	USA	Members of the WomenHeart and FH Foundation databases	2014	National	Descriptive	Survey data	761	86	100	Familial hypercholesterolemia	NR	NR	NR	4
Burns14	2015	Australia	Patients enrolled in the Australian Genetic Heart Disease Registry	NR	National	Descriptive	Survey data	75	NR	73	Long QT syndrome	NR	NR	NR	4
Campbell25	2017	USA	2014 Minnesota State Fair	2014	State	Descriptive	Survey data	971	NR	59	Familial hypercholesterolemia	NR	Study team	NR	3
Cheung20	2010	USA	Tertiary referral cancer center and public county hospital in California	1996–2008	Multi-center	Descriptive	Survey data	1135	60	100	Hereditary breast and ovarian cancer	NR	NR	NR	5
de Souza Silva21	2018	Brazil	Academic medical center	NR	Single-center	Descriptive	Survey data	183	NR	54	Familial hypercholesterolemia	NR	Provider (trained specialized health professional)	NR	3
Dilzell22	2014	USA	(1) Academic medical center, (2) patients affiliated with Lynch Sydnrome International, an advocacy group	2012–2013	National	Descriptive	Survey data	50	91	79	Lynch syndrome	NR	NR	NR	3
Dugueperoux23	2016	France	District in western Brittany where CF incidence is high	1980–2004	Regional	Descriptive	Observational data	128	NR	58	Cystic Fibrosis	NR	NR	NR	3
Finlay24	2008	USA	Academic medical center	2004	Single-center	Descriptive	Survey data	132	93	73	Hereditary breast and ovarian cancer	NR	Study team	NR	4
Hagoel25	2000	Israel	National cancer control center	NR	Single-center	Descriptive	Observational data	438	NR	70	Hereditary breast and ovarian cancer	NR	Patient	NR	4
Hallowell26	2011	Scotland	Regional cascade testing service	2010	Regional	Qualitative	Interview data	38	NR	55	Familial hypercholesterolemia	Yes	Patient	Yes (letters and written material)	3
Hardcastle15	2014	Australia	Lipid disorders clinic in Royal Hospital	NR	Regional	Qualitative	Interview data	18	NR	44	Familial hypercholesterolemia	NR	Screening program	NR	4
Ishii16	2011	Japan	Cancer Institute	2005–2009	Single-center	Descriptive	Survey data	40	NR	63	Lynch syndrome	NR	NR	NR	5
Lerman17	1999	USA	Academic medical center	1996–1998	Single-center	Descriptive	Survey data	139	99	55	Lynch syndrome	NR	Provider	NR	4
Lieberman18	2018	Israel	Medical center	NR	National	Descriptive	Survey data	1771	NR	79	Hereditary breast and ovarian cancer	NR	NR	NR	4
Maxwell19	2009	Australia	Western Australia	2008	Regional	Descriptive	Interview and survey data	430	NR	59	Familial hypercholesterolemia	NR	NR	NR	4
McClaren20	2013	Australia	Children’s Hospital	NR	Single-center	Mixed-methods	Interview data	249	NR	NR	Cystic fibrosis	NR	NR	NR	3
Mesters21	2005	Netherlands	Individuals enrolled in the Netherlands Foundation for the Detection of Hereditary Tumors	NR	National	Qualitative	Interview data	30	NR	73	Lynch syndrome	NR	NR	NR	5
Montgomery22	2013	USA	Fox Chase Cancer Center	2000–2003	Single-center	RCT	RCT data	422	92	100	Hereditary breast and ovarian cancer	NR	Patient	NR	4
Ormondroyd23	2014	UK	Academic medical center	2010–2011	Single-center	Qualitative	Interview data	22	NR	60	Inherited cardiac conditions	NR	Patient	Yes (invitation letter and information sheet)	5
Pentz24	2005	USA	Academic medical center	NR	Single-center	Qualitative	Interview data	80	85	65	Lynch syndrome	NR	Study team	NR	5
Raspa26	2006	USA	National survey research registry	2012	National	Descriptive	Survey data	679 families	92	90	Fragile X syndrome	NR	NR	NR	3
Smart27	2010	UK	Genetics Knowledge Park program	2005–2006	Multi-center	Qualitative	Interview data	27	NR	NR	Inherited cardiac conditions	NR	NR	NR	5
Stoffel28	2008	USA	Cancer genetics clinics in academic medical centers	NR	Multi-center	Descriptive	Survey data	174	91	70	Lynch syndrome	NR	NR	NR	4
Suttman29	2018	USA	Academic medical center	NR	National	Qualitative	Interview data	21	67	0	Hereditary breast and ovarian cancer	NR	NR	NR	5
Truong30	2018	Vietnam	Academic medical center	NR	Single-center	Descriptive	Case series data	112	NR	NR	Familial hypercholesterolemia	NR	Study team	NR	3
Ulph31	2015	England	Research university	2008	National	Qualitative	Interview data	67	68	NR	Cystic Fibrosis	NR	NR	NR	5
van El43	2018	Netherlands	Research university	NR	National	Qualitative	Interview data	6	NR	NR	Familial hypercholesterolemia	NR	Screening program	NR	5
van Maarle33	2001	Netherlands	Academic medical center	1998	National	Descriptive	Survey data	677	NR	54	Familial hypercholesterolemia	NR	Screening program	NR	5
Van Rijn34	1997	Netherlands	University hospital	1997	Single-center	Mixed-methods	Interview data	504	NR	NR	Fragile X Syndrome	NR	Patient	NR	3
Wurtmann35	2018	USA	Academic medical center	2016	Single-center	Descriptive	Survey data	38	89	87	Familial hypercholesterolemia	NR	NR	NR	3