FIGURE 2.

¹⁵N‐HSQC titration data for BRD2 BD‐H2A.Z peptide interactions. (a) ¹⁵N‐HSQC titrations monitoring the addition of the indicated H2A.Z peptides (up to 1.1 mM peptide—~10 molar equivalents) to BRD2‐BD1 (~100 μM). (b) ¹⁵N‐HSQC titrations monitoring the addition of the indicated H2A.Z peptides (up to 1.1 mM peptide—~10 molar equivalents) to BRD2‐BD2 (~100 μM). (c) Binding curves derived by tracking the ¹⁵N CSP in BRD2‐BD1 N97 in response to titration with the indicated H2A.Z peptide variants. The data were fitted to a simple 1:1 binding isotherm using GraphPad. (d). Binding curves derived by tracking the ¹⁵NCSP induced in BRD2‐BD2 D374 in response to titration with the indicated H2A.Z peptide variants. The data were fitted to a simple 1:1 binding isotherm using GraphPad