Table 1.
Characteristics of subjects by vitamin D status
| Vitamin D Deficiency (< 20 ng/mL) N = 35 |
Normal Vitamin D (≥ 20 ng/mL) N = 58 |
p-value | |
|---|---|---|---|
| Median Vitamin D level (ng/mL) | 16 (IQR: 14–18) | 32 (IQR: 26–36) | |
| Cohort Characteristics | |||
| Age (Years) | 58 (IQR: 36–74) | 64 (IQR: 54–73) | 0.13 |
| Sex (% Female) | 18 (51%) | 31 (53%) | 0.85 |
| BMI (kg/m2) | 28.5 (IQR: 23.1–33.8) | 27.0 (IQR: 22.4–32.2) | 0.49 |
| Race (% Black/African American) | 32% | 28% | 0.69 |
|
ICD-Defined Comorbidities: Hypertension Diabetes Chronic Kidney Disease Any Pulmonary Disease |
27 (77%) 23 (66%) 18 (51%) 7 (20%) |
49 (84%) 37 (64%) 28 (48%) 22 (38%) |
0.37 0.85 0.77 0.07 |
| Predefined Outcomes | |||
|
Discharge status: Deceased/Discharged to Hospice Discharged (not death) Still Admitted – Intubated Still Admitted – Not Intubated |
8 (23%) 25 (71%) 2 (6%) 0 (0%) |
14 (24%) 37 (64%) 2 (3%) 5 (9%) |
0.32 |
| Deceased | 8 (23%) | 14 (24%) | 0.89 |
| Ever-Intubated | 10 (29%) | 10 (17%) | 0.20 |
| Length of Intubation (#days) | 8 (IQR: 4–34) | 15 (IQR: 7–23) | 0.69 |
| Renal Replacement (HD or CVVH) | 10 (29%) | 14 (24%) | 0.64 |
| Length of Stay (#days) | 8.8 (IQR: 4.9–16.7) | 9.4 (IQR: 5.0–16.2) | 0.83 |
|
Peak Level Inflammatory Markers: ESR (mm/hr) CRP (mg/L) Ferritin (ng/mL) IL-6 (pg/mL) |
83 (IQR: 54–114) 118 (IQR: 37–274) 1030 (IQR: 555–1802) 12 (IQR: 5–76) |
80 (IQR: 59–110) 131 (IQR: 62–223) 933 (IQR: 311–2165) 26 (IQR: 8–63) |
0.99 0.97 0.65 0.65 |
Values represent median (interquartile range) or frequency (percentages); BMI= body mass index, ICD=International Classification of Diseases, HD=hemodialysis, CVVH=Continuous Veno-Venous Hemofiltration, ESR=erythrocyte sedimentation rate, CRP=C reactive protein, IL-6=interleukin 6