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. 2020 Jul 20;30(12):1109–1126. doi: 10.1038/s41422-020-0378-6

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© Center for Excellence in Molecular Cell Science, CAS 2020

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Fig. 2 — a t-SNE plots showing the expression levels of hepatobiliary marker genes. b Immunofluorescence showing the expression and distribution of FXYD1 and HNF4A in the W12 human (H-W12) and E17.5 mouse (M-E17.5) fetal livers. Scale bars, 20 μm. c Immunofluorescence showing the expression and distribution of GJB1 and HNF4A in the W12 human (H-W12) and E17.5 mouse (M-E17.5) fetal livers. Scale bars, 20 μm. d Immunofluorescence showing the expression and distribution of FGB and HNF4A in the W7 human (H-W7) fetal liver. The yellow arrowhead indicates the FGB⁺HNF4A⁺ hepatoblasts. The white arrowhead indicates the FGB^–HNF4A^– cells. Scale bars, 20 μm. e Schematics of strategies for the generation of Fgb-Cre^ERT2 transgenic mice. f Morphologies and tdTomato signals in the livers of E17.5 WT and Fgb-Cre^ERT2;Rosa26-tdTomato mice. Scale bars, 5 mm. g FACS gating and statistical analysis showing the percentage of tdTomato⁺DLK⁺/DLK⁺ (upper) and tdTomato⁺EpCAM⁺/EpCAM⁺ (lower) cells in E17.5 WT and Fgb-Cre^ERT2;Rosa26-tdTomato mice. n, number of embryos.