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. 2020 Jul 27;14(11):2748–2765. doi: 10.1038/s41396-020-0727-y

Table 3.

The top ten validated “metabolite–host” interaction links that involved metabolites or host targets significantly associated with COPD in the pilot multi-omic cohort (FDR P < 0.1). The validated microbial contributors were shown for each metabolite.

Metabolites Host targets Predicted MoA Metabolite–host Metabolite Host target Validated microbial contributors
Spearman’s R FDR P val Log2 FC FDR P val Log2 FC FDR P val
Butyrate SOD2 Inhibition −0.449 0.017 −0.478 0.625 0.962 0.061 Streptococcus;Fusobacterium
Homocysteine MMP9 Activation 0.400 0.028 0.684 0.273 1.677 0.016 Veillonella;Streptococcus;Neisseria
Palmitate ACSL1 Activation 0.334 0.056 0.561 0.070 1.132 0.091 Rothia;Haemophilus;Campylobacter
Butyrate CXCL8 Inhibition −0.379 0.073 −0.478 0.625 1.193 0.089 Streptococcus;Fusobacterium
Sucrose NOS3 Inhibition −0.410 0.083 0.679 0.232 −0.712 0.075 Prevotella;Neisseria;Haemophilus;Streptococcus
Urate NLRP3 Activation 0.302 0.091 0.248 0.913 1.887 0.085 Pseudomonas;Streptococcus;Prevotella
Palmitate CYP1A1 Activation 0.310 0.108 0.561 0.070 0.768 0.629 Rothia;Haemophilus;Campylobacter
Palmitate NFYC Activation 0.289 0.136 0.561 0.070 1.425 0.085 Rothia;Haemophilus;Campylobacter
Palmitate MYO7A Activation −0.269 0.167 0.561 0.070 0.135 0.832 Rothia;Haemophilus;Campylobacter
N-Acetyl-d-Mannosamine CHI3L1 Inhibition −0.249 0.246 0.267 0.775 −1.355 0.095 Prevotella;Streptococcus