. 2020 Jul 27;14(11):2748–2765. doi: 10.1038/s41396-020-0727-y

Table 3.

The top ten validated “metabolite–host” interaction links that involved metabolites or host targets significantly associated with COPD in the pilot multi-omic cohort (FDR P < 0.1). The validated microbial contributors were shown for each metabolite.

Metabolites	Host targets	Predicted MoA	Metabolite–host		Metabolite		Host target		Validated microbial contributors
Metabolites	Host targets	Predicted MoA	Spearman’s R	FDR P val	Log2 FC	FDR P val	Log2 FC	FDR P val	Validated microbial contributors
Butyrate	SOD2	Inhibition	−0.449	0.017	−0.478	0.625	0.962	0.061	Streptococcus;Fusobacterium
Homocysteine	MMP9	Activation	0.400	0.028	0.684	0.273	1.677	0.016	Veillonella;Streptococcus;Neisseria
Palmitate	ACSL1	Activation	0.334	0.056	0.561	0.070	1.132	0.091	Rothia;Haemophilus;Campylobacter
Butyrate	CXCL8	Inhibition	−0.379	0.073	−0.478	0.625	1.193	0.089	Streptococcus;Fusobacterium
Sucrose	NOS3	Inhibition	−0.410	0.083	0.679	0.232	−0.712	0.075	Prevotella;Neisseria;Haemophilus;Streptococcus
Urate	NLRP3	Activation	0.302	0.091	0.248	0.913	1.887	0.085	Pseudomonas;Streptococcus;Prevotella
Palmitate	CYP1A1	Activation	0.310	0.108	0.561	0.070	0.768	0.629	Rothia;Haemophilus;Campylobacter
Palmitate	NFYC	Activation	0.289	0.136	0.561	0.070	1.425	0.085	Rothia;Haemophilus;Campylobacter
Palmitate	MYO7A	Activation	−0.269	0.167	0.561	0.070	0.135	0.832	Rothia;Haemophilus;Campylobacter
N-Acetyl-d-Mannosamine	CHI3L1	Inhibition	−0.249	0.246	0.267	0.775	−1.355	0.095	Prevotella;Streptococcus