Fig. 1.

Overview of SPACE. a Top navigation bar of SPACE functions. b The search module allows users to search regulatory elements by genomic regions or genes. c Main function of the regulation panel. The upper panel shows the coaccessible peaks of PD-L1 (encoded by CD274). The lower panel shows the potential TFs regulating the LUAD_70975 peak. d The clinical panel allows users to explore the clinical association of a given peak. The five plots show the score distribution across organs, peak score in distinct tumor stages, prognostic value of a peak, tSNE distribution of a given peak, and tSNE of all samples (from left to right). e The immune microenvironment module shows the association between a given peak and 64 immune cells and stromal cells in the tumor microenvironment. f The pathway module allows users to perform gene set enrichment analysis of peak-related genes. g Correlation between BRD4 and LUAD_70975, which can be reproduced in the TF-histone submodule