Table 1.
Effects of colon-delivered SCFAs on serum SCFAs, faecal SCFAs, and serum BDNF.
| Placebo | Low dose | High dose | PInteraction | ||||
|---|---|---|---|---|---|---|---|
| Before | After | Before | After | Before | After | ||
| Serum SCFAs (μM) | N = 22 | N = 22 | N = 21 | N = 22 | N = 21 | N = 21 | |
| Acetate | 42.46 (37.72) | 43.80 (60.02) | 41.93 (24.94) | 79.55 (53.48) | 32.01 (14.74) | 84.08 (39.52) | <0.001 |
| Propionate | 1.99 (1.58) | 1.91 (1.49) | 2.09 (2.16) | 2.52 (2.61) | 1.54 (0.87) | 2.04 (1.54) | 0.001 |
| Butyrate | 0.56 (0.61) | 0.50 (0.39) | 0.46 (0.33) | 0.94 (0.91) | 0.48 (0.27) | 1.40 (1.39) | <0.001 |
| Total SCFAs | 45.02 (49.80) | 46.22 (76.67) | 42.45 (36.19) | 81.25 (77.66) | 34.04 (19.95) | 87.53 (79.73) | <0.001 |
| Faecal SCFAs (mM) | N = 22 | N = 22 | N = 22 | N = 22 | N = 21 | N = 21 | |
|---|---|---|---|---|---|---|---|
| Acetate | 68.21 (26.96) | 53.96 (18.92) | 65.84 (28.28) | 55.17 (20.57) | 72.25 (18.24) | 61.98 (17.42) | 0.87 |
| Propionate | 16.64 (8.78) | 13.47 (8.97) | 18.29 (10.33) | 14.03 (6.33) | 18.35 (8.80) | 14.47 (4.98) | 0.99 |
| Butyrate | 15.39 (7.43) | 10.87 (3.75) | 15.70 (11.90) | 11.96 (4.99) | 15.21 (7.22) | 11.70 (6.17) | 0.81 |
| Total SCFAs | 100.24 (39.78) | 78.30 (28.83) | 99.84 (47.88) | 81.15 (28.28) | 105.82 (31.51) | 88.15 (25.08) | 0.94 |
| Serum BDNF (µg/mL) | N = 22 | N = 22 | N = 21 | N = 22 | N = 21 | N = 21 | |
|---|---|---|---|---|---|---|---|
| 35.88 (11.62) | 35.97 (13.32) | 34.48 (17.25) | 39.39 (16.68) | 39.19 (10.73) | 38.19 (12.13) | 0.11 |
Values represent means and standard deviations. For serum SCFAs, the obtained concentrations were averaged across the four timepoints per participant, and then averaged across participants.
SCFA short-chain fatty acids, BDNF brain-derived neurotrophic factor.