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. 2020 Jul 20;45(13):2289–2298. doi: 10.1038/s41386-020-0772-2

Fig. 1. The sustained AD-like effects of L-655,708 is transcription and translation dependent.

Fig. 1

a Separate cohorts of male and female rats were injected with L-655,708 or vehicle (V) and the FST was carried out 7 days after drug injection. Both 1 and 3 mg/kg of L-655,708 decreased immobility and increased swimming in the FST, *p < 0.05 compared to control vehicle, n = 8–26. b Inhibition of transcription and translation prevented the sustained AD-like effects of L-655,708 in the FST in male rats. Male rats were injected with L-655,708 (3 mg/kg, i.p.) or vehicle 1 h after pretreatment with anisomycin (50 mg/kg, i.p) or actinomycin D (0.5 mg/kg, i.p.). FST was performed 24 h after drug treatment. *p < 0.05 compared to control vehicle; n = 6.