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. 2020 Jul 20;45(13):2289–2298. doi: 10.1038/s41386-020-0772-2

Fig. 2. The sustained AD-like effect of L-655,708 involves AMPA receptor plasticity in the mPFC.

Fig. 2

a Twenty-four hours after either L-655,708 (L6, 3 mg/kg, i.p.) or vehicle (V) was given, male rats were administered vehicle or NBQX (300 µM, 0.5 µl) directly into the mPFC immediately before the FST was carried out. NBQX blocked the decrease in immobility and the increase in climbing produced by L-655,708; *p < 0.05 compared to control vehicle, n = 7–8. b L-655,708 produced increased levels of GluA1 in mPFC 24 h after administration of drug; *p < 0.05, n = 4.