Table 2.

Group and Drug main effects on spindles, slow oscillations, and their coordination.

	Group main effect						Drug main effect
	Control (M ± SD)	Schiz. (M ± SD)	Control vs. Schiz. (partial-η2)	Cluster statistics			Placebo (M ± SD)	Eszopicl. (M ± SD)	Eszopicl. vs. Placebo (partial-η2)	Cluster statistics
				No. of electrodes	tsum	p				No. of electrodes	tsum	p
Spindles
Density (#/min)	2.6 ± 1.3	1.9 ± 1.0	0.10	32	76	0.03*	2.2 ± 1.3	2.6 ± 1.3	0.30	58	277	<0.001*
Amplitude (μV)	12.4 ± 2.8	11.8 ± 3.5	0.01	-	-	-	12.0 ± 3.2	12.3 ± 3.1	0.04	-	-	-
Frequency (Hz)	13.07 ± 0.33	13.02 ± 0.38	0.01	-	-	-	13.14 ± 0.37	13.07 ± 0.36	0.17	33	−106	<0.001*
Duration (s)	0.84 ± 0.07	0.83 ± 0.09	0.01	-	-	-	0.83 ± 0.08	0.85 ± 0.08	0.30	49	197	<0.001*
Spindle sigma (μV2/Hz)	8.7 ± 4.2	8.0 ± 4.7	0.01	-	-	-	8.8 ± 4.6	9.8 ± 5.3	0.13	27	76	0.006*
N2 sigma (μV2/Hz)	0.63 ± 0.34	0.54 ± 0.32	0.02	-	-	-	0.61 ± 0.35	0.70 ± 0.40	0.16	33	106	0.002*
Slow oscillations (SO)
Density (#/min)	4.5 ± 0.6	4.9 ± 1.0	0.06	-	-	-	4.7 ± 0.8	4.8 ± 0.8	0.04	-	-	-
Amplitude (μV)	66 ± 15	65 ± 17	0.002	-	-	-	69 ± 16	62 ± 15	0.37	58	−329	<0.001*
Duration (s)	1.06 ± 0.04	1.06 ± 0.05	0.02	-	-	-	1.05 ± 0.04	1.07 ± 0.04	0.22	37	144	0.002*
Spindle–SO coordination
Coupled density (#/min)	0.48 ± 0.21	0.47 ± 0.23	0.01	-	-	-	0.44 ± 0.21	0.51 ± 0.22	0.26	55	238	<0.001*
Consistency	0.41 ± 0.13	0.53 ± 0.15	0.18	37	−123	0.01*	0.49 ± 0.15	0.44.15	0.20	54	−190	<0.001*
Phase (°)	8 ± 25°	2 ± 22°	0.02	-	-	-	6 ± 24°	4 ± 24°	0.04	-	-	-

Means, SDs, and effect sizes are based on data averaged across nights. Descriptive statistics are averaged across electrodes within significant clusters (otherwise across all electrodes).

* denotes that the cluster meets a corrected threshold of p<.05.