TABLE 2.

SRS subscore comparison stratified by genotype, sex, and ASD status

	Social awareness		Social cognition		Social communication		Social motivation		RRB		SCI
	Mean ± SD	p Value	Mean ± SD	p Value	Mean ± SD	p Value	Mean ± SD	p Value	Mean ± SD	p Value	Mean ± SD	p Value
Genotype
Control	47.04 ± 8.88	–	45.27 ± 7.64	–	45.88 ± 8.14	–	46.13 ± 7.66	–	47.66 ± 8.51	–	45.50 ± 7.74	–
3q29dup	72.53 ± 16.69	1.43E-10	74.53 ± 18.45	4.27E-13	77.27 ± 17.65	3.37E-14	71.13 ± 14.89	3.61E-12	81.47 ± 20.28	1.48E-13	77.27 ± 18.43	3.24E-14
Sex
Male control	45.97 ± 9.15	–	45.23 ± 7.42	–	45.73 ± 6.34	–	46.57 ± 6.58	–	47.63 ± 5.59	–	45.37 ± 6.60	–
Male 3q29dup	71.83 ± 23.66	.0003	78.67 ± 22.41	1.04E-06	78.83 ± 21.64	3.27E-07	73.33 ± 13.35	3.72E-07	85.83 ± 23.81	6.41E-08	79.67 ± 22.13	3.38E-07
Female control	48.27 ± 8.56	–	45.31 ± 8.03	–	46.04 ± 9.95	–	45.62 ± 8.85	–	47.69 ± 11.08	–	45.65 ± 9.01	–
Female 3q29dup	73.00 ± 11.72	1.47E-07	71.78 ± 16.15	6.24E-07	76.22 ± 15.80	1.82E-07	69.67 ± 16.45	6.74E-06	78.56 ± 18.47	9.13E-07	75.67 ± 16.76	1.71E-07
ASD status
Control	47.04 ± 8.88	–	45.27 ± 7.64	–	45.88 ± 8.14	–	46.13 ± 7.66	–	47.66 ± 8.51	–	45.50 ± 7.74	–
No ASD diagnosis 3q29dup	68.22 ± 17.09	1.74E-06	70.33 ± 19.66	1.50E-08	72.00 ± 18.73	3.56E-09	67.11 ± 16.83	1.00E-07	75.56 ±21.37	1.29E-08	72.00 ± 19.72	3.31E-09
ASD diagnosis 3q29dup	79.00 ± 15.15	5.86E-09	80.83 ± 15.99	1.24E-10	85.17 ± 13.64	2.85E-12	77.17 ± 9.77	3.80E-10	90.33 ± 16.23	7.50E-12	85.17 ± 14.27	3.15E-12

Note: Comparison of mean scores on the SRS subscales between study participants with 3q29dup and controls. Participants with 3q29dup were stratified by sex and ASD status for further analysis. p Values were calculated using simple linear regression, adjusting for age, race, and sex.

Abbreviations: ASD, autism spectrum disorder; RRB, Restricted Interests and Repetitive Behaviors; SCI, Social Communication and Interaction; SRS, Social Responsiveness Scale.