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. Author manuscript; available in PMC: 2021 Jan 5.
Published in final edited form as: Am J Med Genet A. 2020 Mar 10;182(5):1152–1166. doi: 10.1002/ajmg.a.61540

TABLE 2.

SRS subscore comparison stratified by genotype, sex, and ASD status

Social awareness
Social cognition
Social communication
Social motivation
RRB
SCI
Mean ± SD p Value Mean ± SD p Value Mean ± SD p Value Mean ± SD p Value Mean ± SD p Value Mean ± SD p Value
Genotype
  Control 47.04 ± 8.88 45.27 ± 7.64 45.88 ± 8.14 46.13 ± 7.66 47.66 ± 8.51 45.50 ± 7.74
  3q29dup 72.53 ± 16.69 1.43E-10 74.53 ± 18.45 4.27E-13 77.27 ± 17.65 3.37E-14 71.13 ± 14.89 3.61E-12 81.47 ± 20.28 1.48E-13 77.27 ± 18.43 3.24E-14
Sex
  Male control 45.97 ± 9.15 45.23 ± 7.42 45.73 ± 6.34 46.57 ± 6.58 47.63 ± 5.59 45.37 ± 6.60
  Male 3q29dup 71.83 ± 23.66 .0003 78.67 ± 22.41 1.04E-06 78.83 ± 21.64 3.27E-07 73.33 ± 13.35 3.72E-07 85.83 ± 23.81 6.41E-08 79.67 ± 22.13 3.38E-07
  Female control 48.27 ± 8.56 45.31 ± 8.03 46.04 ± 9.95 45.62 ± 8.85 47.69 ± 11.08 45.65 ± 9.01
  Female 3q29dup 73.00 ± 11.72 1.47E-07 71.78 ± 16.15 6.24E-07 76.22 ± 15.80 1.82E-07 69.67 ± 16.45 6.74E-06 78.56 ± 18.47 9.13E-07 75.67 ± 16.76 1.71E-07
ASD status
  Control 47.04 ± 8.88 45.27 ± 7.64 45.88 ± 8.14 46.13 ± 7.66 47.66 ± 8.51 45.50 ± 7.74
  No ASD diagnosis 3q29dup 68.22 ± 17.09 1.74E-06 70.33 ± 19.66 1.50E-08 72.00 ± 18.73 3.56E-09 67.11 ± 16.83 1.00E-07 75.56 ±21.37 1.29E-08 72.00 ± 19.72 3.31E-09
  ASD diagnosis 3q29dup 79.00 ± 15.15 5.86E-09 80.83 ± 15.99 1.24E-10 85.17 ± 13.64 2.85E-12 77.17 ± 9.77 3.80E-10 90.33 ± 16.23 7.50E-12 85.17 ± 14.27 3.15E-12

Note: Comparison of mean scores on the SRS subscales between study participants with 3q29dup and controls. Participants with 3q29dup were stratified by sex and ASD status for further analysis. p Values were calculated using simple linear regression, adjusting for age, race, and sex.

Abbreviations: ASD, autism spectrum disorder; RRB, Restricted Interests and Repetitive Behaviors; SCI, Social Communication and Interaction; SRS, Social Responsiveness Scale.