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. 2021 Jan 5;9(1):e14606. doi: 10.14814/phy2.14606

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© 2021 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Nuclear content of the atrophy‐inducing transcription factor p53 is dramatically increased following 7 days of hindlimb unloading, even in losartan‐treated animals. Western blot detection of p53 in the nuclear fraction of soleus muscles. Ponceau S Red (PR) stain (~42 kDa mark) used as a loading control for western blotting quantification. Values are presented as fold control of mean ± SEM. Values sharing the same letter are not significantly different (p < .05): ^aindicates different from CON; ^cindicates different from HUL; ^dindicates different from CONL