Table 1.

Tigecycline international in vitro susceptibility breakpoints.

Bacterial family/species	International breakpoints standard	Broth microdilution (mg/L)	Disk diffusion (mm)
Enterobacteriaceae	EUCAST	S ≤ 0.5, R > 0.5	S ≥ 18, R < 18
	FDA	S ≤ 2, R ≥ 8	S ≥ 19, R ≤ 14
	BSAC	S ≤ 1, R > 2	S ≥ 24, R ≤ 19
Staphylococcus spp.	EUCAST	S ≤ 0.5, R > 0.5	S ≥ 18, R < 18
	FDA	S ≤ 0.5	S ≥ 19
	BSAC	S ≤ 0.5, R > 0.5	S ≥ 26, R ≤ 25
Enterococcus spp.	EUCAST	S ≤ 0.25, R > 0.25	S ≥ 18, R < 18
	FDA	S ≤ 0.25	S ≥ 19
	BSAC	S ≤ 0.25, R > 0.5	S ≥ 21, R < 20
Streptococcus groups A, B, C and G	EUCAST	S ≤ 0.125, R > 125	S ≥ 19, R < 19
	FDA	S ≤ 0.25	S ≥ 19
	BSAC	S ≤ 0.25, R > 0.5	S ≥ 25, R < 19
Streptococcus pneumoniae	EUCAST	-	-
	FDA	S ≤ 0.06	S ≥ 19
	BSAC	-	-
Clostridioides difficile	EUCAST	S ≤ 0.25, R > 0.25	-
	FDA	S ≤ 4, R > 16	-
	BSAC	S ≤ 0.25	-
Acinetobacter spp.	EUCAST	-	-
	FDA	S ≤ 2, R ≥ 8	-
	BSAC	S ≤ 1, R > 2	S ≥ 20, R < 20
Pseudomonas spp.	EUCAST	-	-
	FDA	S ≤ 2, R ≥ 8	-
	BSAC	-	-

EUCAST European Committee on Antimicrobial Susceptibility Testing, FDA Food and Drug Administration, BSAC British Society for Antimicrobial Chemotherapy, S sensitive, R:Resistance