Table 3.

In Vitro Transcorneal Permeability Parameters of PRG from Multiple W/O/W MEs^a and Controls^b

formulation	rate of permeation (dM/dt)	flux (μg/cm2/min)	permeability coefficient (P) × 104 (cm/min)
PRGc in water	0.285 ± 0.04	0.45 ± 0.06	7.5 ± 0.92
PRG in Carbopol 981	0.374 ± 0.06	0.59 ± 0.10	9.8 ± 1.61
PRG chitosan ME	0.233 ± 0.03	0.37 ± 0.04	6.1 ± 0.69
PRG sodium alginate ME	0.287 ± 0.07	0.45 ± 0.12	7.5 ± 1.93
PRG Carbopol 981 ME	0.288 ± 0.04	0.45 ± 0.06	7.6 ± 0.98

^aW/O/W MEs: water-in-oil-in-water microemulsions.

^bData are expressed as mean ± SEM; n = 6.

^cPRG: pregabalin. p value that represents the outcome of the one-way ANOVA analysis is 0.4191.