Table 4.

Pharmacodynamic Parameters after Topical Application of Single Dose of Different Pregabalin Formulations to Dutch Belted Rabbits^a

	ophthalmic eye drops
pharmacodynamic parameters	PRGb chitosan MEc	PRG sodium alginate ME	PRG Carbopol 981 ME	PRG in Carbopol 981	PRG W/O ME
baseline IOPd	21.2 ± 0.4	20.9 ± 0.2	21.4 ± 0.7	22.1 ± 0.4	16.7 ± 1.2
IOP at Tmaxe	13.9 ± 1.0	13.6 ± 0.2	12.3 ± 0.5	15.7 ± 0.4	12.7 ± 0.7
ΔIOP	−7.3 ± 1.3	−7.3 ± 0.4	−9.1 ± 0.8	−6.5 ± 0.4	−4.0 ± 0.58
% reduction in IOP	34.1 ± 5.4	35.0 ± 1.7	42.3 ± 2.6	29.4 ± 1.4	23.8 ± 1.9
Tmax (h)	4.0 ± 1.0	3.7 ± 0.3	3.3 ± 0.9	3.3 ± 1.5	2.33 ± 0.33
Tendf (h)	20.0 ± 0.0	24.0 ± 0.0	32.7 ± 1.3	9.3 ± 0.7	7.33 ± 1.33
AUCg (%. H)	323.0 ± 27.0	384.3 ± 21.2	788.6 ± 36.8	172.3 ± 16.9	98.9 ± 13.8

^aData are expressed as mean ± SEM; n = 3.

^bPRG: pregabalin.

^cME: microemulsion.

^dIOP: intraocular pressure.

^eT_max: time to maximum response in hours.

^fT_end (h): time to end of response in hours.

^gAUC (%. H): total area under % IOP reduction versus time curve