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. 2020 Dec 21;16(12):e1008495. doi: 10.1371/journal.pcbi.1008495

Fig 1. Contour lines.

Fig 1

Plots show the contour lines of two functions, chosen to illustrate identifiable and non-identifiable cases. Plot (A) is an identifiable case illustrated by Booth function lA(θ) = (θ1+2θ2−7)2+(2θ1+θ2−5)2, which has known minimum lA(1,3) = 0. Plot (B) illustrate non-identifiable case by Rosenbrock function lB(θ)=(1θ1)2+100(θ2θ12)2 with minimum lB(1,1) = 0. The star-shaped points mark the minima of the above functions. The bold contour represents the CRα={θ:l(θ)lα*0} for lα*=200. The dashed lines are profile paths projected on (θ1, θ2) Red circles mark the points where tangent hyperplanes correspond to parameters’ minimal or maximal values in CRα. Red circles are CI endpoints. The contours were calculated using marching squares algorithm implemented in Contour.jl package (https://github.com/JuliaGeometry/Contour.jl). They are provided for illustrative purposes only.