Table 2.
Clinical characteristics for SEARCH (N=2,283) and YDR (N=2,331) youth by diabetes type, incident years 2006, 08, 12 for SEARCH and 2006–2012 for YDR
| Variables | Type 1 diabetes |
p-value | Type 2 diabetes |
p-value | ||
|---|---|---|---|---|---|---|
| SEARCH^ |
YDR |
SEARCH^ |
YDR |
|||
| 2006–2012 n=1,899 | 2006–2012 n=2,104 | 2006–2012 n=384 | 2006–2012 n=227 | |||
| Age at diagnosis (yrs), mean (SD) | 10.1 (4.3) | 10.5 (4.9) | <0.001 | 14.4 (2.7) | 16.1 (2.8) | <0.001 |
| Age at baseline visit (yrs), n (%) | <0.001 | <0.001 | ||||
| 0–4 | 198 (10.4) | 296 (14.1) | 0 | 0 (0.0) | ||
| 5–9 | 548 (28.9) | 612 (29.1) | 7 (1.8) | 8 (3.5) | ||
| 10–14 | 786 (41.4) | 698 (33.2) | 157 (40.9) | 48 (21.1) | ||
| 15–19 | 354 (18.6) | 443 (21.1) | 199 (51.8) | 151 (66.5) | ||
| 20+ | 13 (0.7) | 55 (2.6) | 21 (5.5) | 20 (8.8) | ||
| Duration of diabetes (mos), mean (SD) | 10.3 (7.4) | 6.2 (9.7) | <0.001 | 13.3 (8.2) | 7.0 (10.5) | <0.001 |
| Height (cm), mean (SD) | 146.6 (23.0) | 144.5 (24.3) | <0.001 | 166.0 (11.4) | 156.9 (18.0) | <0.001 |
| Weight (kg), mean (SD) | 45.8 (21.6) | 32.9 (16.6) | <0.001 | 98.4 (27.1) | 68.6 (21.5) | <0.001 |
| BMI z-score (WHO), mean (SD) | 0.69 (1.23) | −0.54 (1.65) | <0.001 | 3.17 (1.15) | 1.65 (2.10) | <0.001 |
| BMI Catergories, n (%) | <0.001 | <0.001 | ||||
| Underweight | 11 (0.6) | 319 (15.2) | 0 (0.0) | 9 (4.0) | ||
| Normal | 1144 (60.2) | 1280 (60.8) | 10 (2.6) | 46 (20.3) | ||
| Overweight | 400 (21.1) | 159 (7.6) | 25 (6.5) | 49 (21.6) | ||
| Obese | 231 (12.2) | 90 (4.3) | 303 (78.9) | 83 (36.6) | ||
| Missing | 113 (6.0) | 256 (12.2) | 46 (12.0) | 40 (17.6) | ||
| Blood pressure, mean (SD) | <0.001 | <0.001 | ||||
| SBP | 99.7 (11.8) | 105.5 (15.0) | 115.9 (12.6) | 119.2 (14.5) | ||
| DBP | 63.3 (9.6) | 69.0 (10.0) | 72.0 (10.1) | 78.3 (9.3) | ||
| Hypertension*, n (%) | 53 (3.0) | 171 (14.2) | <0.001 | 59 (15.7) | 46 (23.5) | <0.001 |
| A1c, mean (SD) | 7.8 (1.7) | 11.0 (2.9) | <0.001 | 7.2 (2.1) | 9.9 (2.8) | <0.001 |
| A1c Categories, n (%) | <0.001 | <0.001 | ||||
| Less than 7.5 | 797 (42.0) | 151 (7.2) | 260 (67.7) | 41 (18.1) | ||
| 7.5–9.0 | 620 (32.6) | 214 (10.2) | 50 (13.0) | 29 (12.8) | ||
| Greater than 9.0 | 355 (18.7) | 959 (45.6) | 64 (16.7) | 98 (43.2) | ||
| Missing | 127 (6.7) | 780 (37.1) | 10 (2.6) | 59 (26.0) | ||
^
a subset of SEARCH participants diagnoised in 2006, 2008, and 2012 who completed a baseline visit (a SEARCH baseline research visit)
*
SEARCH T1D (n=1795), T2D (n=377); YDR T1D (n=1204), T2D (n=196)