Table 3.
Mean percent parasitaemia and mean percent parasitemia inhibition of P. berghei-infected mice treated with hydromethanolic crude extract and chloroform fraction of G. ternifolia leaves in the Rane's test.
| Extract | Day 3 % parasitemia | Day-4 % parasitemia | Day 5 | Day 6 % parasitemia | Day 7 % parasitemia | |
|---|---|---|---|---|---|---|
| % parasitemia | % para. inhibition | |||||
| CON 10 ml/kg | 14.10 ± 0.54 | 35.00 ± 0.56 | 43.00 ± 1.58 | 0 | 0 | 0 |
| CM 100 mg/kg | 15.00 ± 0.37 | 34.00 ± 0.83 | 32.00 ± 0.45 | 25.58acde (3) | 25.03 ± 0.59 | 21.00 ± 0.48 |
| CM 200 mg/kg | 14.03 ± 0.60 | 27.03 ± 0.81 | 27.10 ± 0.40 | 36.98 abe (3) | 21.00 ± 0.46 | 17.05 ± 0.34 |
| CM 400 mg/kg | 15.10 ± 0.18 | 26.07 ± 0.46 | 22.03 ± 0.22 | 48.76 abe (3) | 19.00 ± 0.60 | 14.03 ± 0.23 |
| CF 100 mg/kg | 12.13 ± 0.20 | 29.00 ± 0.30 | 23.07 ± 0.33 | 46.36 ade (3) c1 | 21.00 ± 0.37 | 16.90 ± 0.23 |
| CF 200 mg/kg | 14.05 ± 0.31 | 25.00 ± 0.24 | 15.97 ± 0.32 | 62.87 ade (3) b1 | 11.10 ± 0.16 | 10.03 ± 0.35 |
| CF 400 mg/kg | 15.13 ± 0.53 | 20.00 ± 0.52 | 11.00 ± 0.47 | 74.42 abce (3) | 9.00 ± 0.16 | 7.17 ± 0.26 |
| CQ 10 mg/kg | 13.10 ± 0.38 | 7.07 ± 0.14 | 3.07 ± 0.22 | 92.87 abcd (3) | 0.00 ± 0.00 | 0.00 ± 0.00 |
Data are expressed as mean ± SEM; (n = 6: CQ = chloroquine, CON = control, CM, crude hydromethanolic extract, CF = chloroform fraction of Gardenia ternifolia, % par supp = % parasitemia suppression). a, compared to negative control; b, compared to100 mg/kg; c, compared to 200 mg/kg; d, compared to 400 mg/kg; e, compared to CQ10 mg/kg: 1P < 0.05, 3P < 0.001.