Table 2.
Univariate and multivariate analyses for overall survival in PESCC.
| Prognostic factor | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Sex | ||||||
| Male vs. female | 0.682 | 0.389-1.194 | 0.180 | |||
| Age | ||||||
| ≤60 vs. >60 | 1.384 | 0.818-2.342 | 0.226 | |||
| Location | ||||||
| Upper third vs. middle and lower thirds | 1.134 | 0.486-2.647 | 0.771 | |||
| aT classification | ||||||
| T1-2 vs. T3-4 | 1.964 | 1.148-3.359 | 0.014 | |||
| aN classification | ||||||
| N0 vs. N1-2 | 0.363 | 0.207-0.637 | <0.001 | |||
| aM classification | ||||||
| M0 vs. M1 | 3.933 | 1.945-7.950 | <0.001 | |||
| aStage | ||||||
| I-II vs. III-IV | 2.493 | 1.463-4.248 | 0.001 | 2.334 | 1.323-4.118 | 0.003 |
| Necrosis | ||||||
| No vs. yes | 1.761 | 1.027-3.021 | 0.040 | |||
| bTIIs | ||||||
| Poor vs. rich | 0.628 | 0.378-1.044 | 0.073 | |||
| CD4 | ||||||
| Poor vs. rich | 1.696 | 0.981-2.934 | 0.059 | 1.935 | 1.068-3.507 | 0.030 |
| FoxP3 | ||||||
| Poor vs. rich | 1.807 | 1.038-3.145 | 0.036 | |||
| CD8 | ||||||
| Poor vs. rich | 0.568 | 0.312-1.033 | 0.064 | |||
| CD163 | ||||||
| Poor vs. rich | 0.762 | 0.432-1.345 | 0.349 | |||
| PD-L1 | ||||||
| Negative vs. positive | 0.578 | 0.333-1.000 | 0.050 | 0.480 | 0.267-0.860 | 0.014 |
| FoxP3/CD8 | ||||||
| Low vs. high | 1.842 | 1.091-3.108 | 0.022 | 1.727 | 1.015-2.938 | 0.044 |
| CD8/CD4 | ||||||
| Low vs. high | 0.590 | 0.344-1.012 | 0.055 | |||
aTNM stage: the AJCC (8th edition) was used; bTIIs: tumor-infiltrating immune cells.