Figure 12.

IronQ-induced CACs promoted tube-like formations during coculturing with HUVECs. (a) Representative endothelial tube formation following 24 h of incubation with CACs and their conditioned medium in Matrigel®. Control: HUVEC in the growth medium, HUVEC + CACs: HUVEC coculture with CACs and the condition medium of CACs. Scale bars = 100 μm. (b), (c) Graph showing the average endothelial tube number and tube length (μm). Notably, this assay was performed 8 independent times on matched samples from 8 different donors (^∗p < 0.05).