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. 2020 Oct 6;141(1):101–116. doi: 10.1007/s00401-020-02230-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Landscape of somatic alterations in SWNTS-SWNs. a Oncoprint showing results from WES analysis of 29 SWNTS-SWNs and 25 NS-SWNs. Mutation spectrum and CNV fraction are plotted on the top. COSMIC signatures 1A, 6, 15, and 20 in each cohort are also depicted. Somatic mutations and deletions in NF2, LZTR1, and SMARCB1 are shown. Distribution of zero, one, two, or three somatic hits across the two cohorts are shown as pie charts below. b Oncoprint showing top deleterious somatic variants (based on SIFT and PolyPhen2) identified by both WES and WGS methods in 16 overlapping samples. Clinical and molecular annotations are depicted above and below the oncoprint. Venn diagram to the right shows the number of variants called by both WES and WGS. c Plots showing compounded arm-level CNV in SWNTS-SWNs versus NS-SWNs. d GISTIC plots showing significant focal deletions in SWNTS-SWNs and NS-SWNs