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Summary of key molecular alterations in SWNTS-SWNs. Diagram showing key genomic alterations detected in SWNTS-SWNs and in comparison with NS-SWNs. These include differences in immune cell proportions, CNV, somatic alterations in chromosome 22q, and anatomic location associated with pain in SWNTS-SWNs. We also depicted similarities among SWNTS-SWNs and NS-SWNs with respect to COSMIC MMR signatures, presence of SH3PXD2A-HTRA1 gene fusion, and activation of key oncogenic pathways
