Fig. 3.

Molecular alterations of primary mismatch repair-deficient IDH-mutant astrocytomas. a Distribution of IDH mutations in PMMRDIA compared to reference cohorts. b Oncoprint showing selected genetic alterations in PMMRDIA. Red numbers indicate that a blood control was available. c Mutational burden in IDH-mutant gliomas (PMMRDIA, primary MMR-deficient IDH-mutant astrocytoma n = 17; A supra, astrocytoma supratentorial n = 15; HGA supra, high-grade astrocytoma supratentorial n = 22; A infra, astrocytoma infratentorial n = 9; O, oligodendroglioma 1p/19q codeleted n = 17). d Pathogenic alterations in PMMRDIA in RAS/PI3K/AKT signaling pathway