Table 2.

Distribution of selected variants in IDH-mutant gliomas

Cohort	Primary MMR-deficient astrocytoma	Astrocytoma supratentorial	High grade astrocytoma supratentorial	Astrocytoma infratentorial	Oligodendroglioma 1p/19q codeleted
n	17	15	22	9	17
MSH6	53.3% (8/15)	13.3% (2)	9.1% (2)	0	0
MLH1	14.3% (2/14)	0	0	0	5.9% (1)
MSH2	14.3% (2/14)	0	0	0	0
TP53	94.1% (16/17)	80% (12)	95.5% (21)	88.9% (8)	5.9% (1)
ATRX	80% (12/15)	53.3% (8)	59.1 (13)	33.3% (3)	0
PDGFRA	35.3% (6/17)	0	9.1% (3)	11.1% (1)	5.9% (1)
PIK3CA	35.3% (6/17)	0	18.2% (4)	11.1% (1)	5.9% (1)
RB1	23.5% (4/17)	13.3% (2)	4.6% (1)	0	0
NF1	17.6% (3/17)	0	9.1% (3)	11.1% (1)	0
PTEN	11.8% (2/17)	0	0	0	0
PTPN11	11.8% (2/17)	0	0	0	0