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Model for the development of multiple myeloma based on the latest whole genome sequencing data. Compared to previous model we proposed here the existence of a pre-MGUS GC-phase. Recent data suggest that the pre-MGUS cell experienced a prolonged exposure to the GC. During these exposures several key drivers and AID mediated mutations are acquired. At certain point, this clone becomes GC-independent and move to the bone marrow, where it starts the MGUS>SMM>MM evolution.
