Table 2.

Candidate CpGs in the IOW cohort (n=122) and their replication in the Born Into Life cohort (n=33)

		IOW cohort						Born into life cohort
			Ttscreening			Mixed model
CpGs	Gene names	Selection Probability	Estimate# M values	P-value	FDR adjusted p-value	Estimate* β values	P-value*	Estimate⸸ β values	P-value⸸
cg01816814	LMF1	89%	−0.00034	4.68 E-06	0.0004	−45843	<.0001	−38027	0.06
cg04255048	KIF9; KLHL18	85%	0.00015	8.83 E-05	0.0007	25719	0.0003	23602	0.27
cg10715265	DAB1	84%	0.00025	8.18 E-06	0.0004	23208	<.0001	8991	0.39
cg23153661	VAX2; CD207	82%	0.00016	2.50 E-05	0.0006	6090.19	<.0001	3291	0.175
cg00249511	SCT	81%	−0.00067	4.16 E-06	0.0004	−15925	<.0001	−494	0.92
cg27239144	SCYL2; DEPDC4	81%	0.00011	7.28 E-05	0.0007	14176	0.0006	−2247	0.79
cg17722033	NECAP1	80%	0.00012	1.85 E-05	0.0006	23160	<.0001	11840	0.166
cg27394038	SFRS3	80%	0.00015	6.37 E-06	0.0004	19565	0.0001	6326	0.57

^#Controlled for newborns’ gender and maternal peripheral blood cell proportions (CD4, neutrophils, eosinophils, B-lymphocytes, natural killer cells, monocytes)

^*Adjusted for newborns’ gender, maternal peripheral blood cell proportions (CD4, neutrophils, eosinophils, B-lymphocytes, natural killer cells, monocytes), maternal smoking during pregnancy, socioeconomic status, and repeated measurements in linear mixed models

^⸸Adjusted for newborns’ gender