Figure 4:

Performance of the cross-validated model from Early Primary CRC Detection Pilot Study using MDMs in Plasma in patients from MDM Plasma CRC Surveillance Study. (A) The distribution of the probability of CRC being present in the surveillance dataset for each of the patient groups. The blue shaded area indicates where the algorithm derived from training data made positive calls in the test set. (B) ROC curves of MDM models with and without CEA and CEA alone for recurrent CRC versus normal controls with corresponding AUCs and 95% confidence intervals. CRC: colorectal cancer; ROC: receiver operating characteristic; NED: no radiographic evidence of disease; AUC: area under the curve; MDM: methylated DNA marker.