Table 1:
Patient and treatment characteristics and their univariate correlation (HR [95% confidence interval (CI)] and p-value) with RP2+
| Variable | N (%) | HR [95% CI] | p-value |
|---|---|---|---|
| Age, median (range), yrs | 67 (28-87) | 1.0547 [1.0963-1.0148] | 0.0058 |
| Sex | |||
| Female | 170 (59.6%) | 1 | |
| Male | 115 (40.4%) | 1.79 [0.931-3.45] | 0.081 |
| KPS, median (range) | 90 (70-100) | 0.989 [0.952-1.03] | 0.63 |
| Clinical Stage (prior to surgery) | |||
| I-II | 106 (37.3%) | 1 | |
| III | 179 (62.7%) | 1.36 [0.381-1.42] | 0.36 |
| Smoking Status | |||
| Never (a) | 50 (17.6%) | 1 | |
| Former (b) | 212 (74.3%) | 0.710 [0.327-1.539] | 0.37 |
| Current (c) | 23 (8.1%) | 0.236 [0.029-1.935] | 0.17 |
| Smokers (b&c), Pack Years, median (range) | 30 (0-165) | 0.994 [0.978-1.01] | 0.48 |
| Smokers (b), Years since quitting, median (range) | 11 (0-55) | 1.02 [0.995-1.05] | 0.12 |
| Chemotherapy Use | 263 (92.3%) | ||
| Preoperative | 150 (57.0%) | 1 | |
| Postoperative | 113 (43.0%) | 1.5 [0.75-3.01] | 0.25 |
| Type of Chemotherapy | |||
| Cisplatin-based | 166 (63.1%) | 1 | |
| Carboplatin-based | 97 (36.9%) | 2.319 [1.189-4.522] | 0.012 |
| Type of Surgery | |||
| Wedge Resection | 29 (10.2%) | 1 | |
| Segment Resection | 5 (1.8%) | 1.031 [0.119-8.943] | 0.98 |
| Lobectomy | 232 (81.3%) | 0.559 [0.227-1.375] | 0.20 |
| Pneumonectomy | 19 (6.7%) | 0.231 [0.027-2.005] | 0.18 |
| Surgical Resection Margin Status | |||
| R0 | 230 (80.6%) | 1 | |
| R1 | 55 (19.4%) | 0.952 [0.621-1.46] | 0.82 |
| R2 | 0 (0%) | ||
| Radiation Technique | |||
| IMRT | 201 (70.4%) | 1 | |
| 3DCRT | 84 (29.6%) | 1.5 [0.682-3.29] | 0.31 |
| Radiation Prescription Dose, median (range), Gy | 54 (45-70) | 0.955 [0.864-1.055] | 0.35 |
| 45-50 Gy | 40 (14%) | ||
| 50-54 Gy | 202 (71%) | ||
| 56-66 Gy | 42 (15%) | ||
| 70 Gy | 1 (0%) |