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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Mol Cancer Res. 2020 Nov 2;19(1):42–47. doi: 10.1158/1541-7786.MCR-20-0704

Figure 1. PR is not expressed in most cervical cancers.

Figure 1.

(A) The majority of cancers developed on the Pgrf/+ and Cre/Pgrf/+ backgrounds are negative for PR. Cervical cancer sections were stained for PR (green). Nuclei are pseudo-colored red. Dotted lines separate cervical cancer (cc) and epithelium (ep) from stroma (st). Numbers are percentages of PR− and PR+ cancer in each genotype. A Pgr−/− cervical section was used as a negative control. Scale bar, 50 μm. (B) Cancer-associated epithelium has lower PR expression than normal epithelium. Cervical cancer-containing sections were stained for PR (green) and nuclei (red). H&E staining of corresponding regions are shown in Supplementary Figure 1B. Scale bar, 50 μm. (C) ERα is undetectable in most PR− cancers. Randomly selected PR− (33 out of 62) and PR+ cancers (20 out of 37) from Pgrf/+ and Cre/Pgrf/+ genotypes were stained for ERα (green) and nuclei (red). Dotted lines separate cervical cancer (cc) from stroma (st). An Esr1−/− cervical section was used as a negative control. Scale bar, 50 μm.