Table 2:
Association between demographics and subjective measures assessed at Week 20 and support for a nicotine reduction policy at Week 20
| All participants | ||||
|---|---|---|---|---|
| Covariate | Unadjusted Analyses | Adjusted Analyses# | ||
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Treatment = Gradual | 0.97 (0.69, 1.37) | 0.883 | ||
| Treatment = Immediate | 1.01 (0.71, 1.43) | 0.952 | ||
| Age = 18–24 | 0.52 (0.30, 0.91) | 0.023 | 0.53 (0.28, 0.99) | 0.048* |
| Gender = Male | 0.42 (0.32, 0.54) | < 0.001 | 0.49 (0.37, 0.67) | < 0.001* |
| Race = Non-white | 0.78 (0.59, 1.01) | 0.063 | 0.98 (0.67, 1.42) | 0.903 |
| Education = HS or less | 0.76 (0.58, 0.99) | 0.039 | 1.11 (0.81, 1.51) | 0.521 |
| Menthol = Yes | 0.74 (0.57, 0.96) | 0.025 | 0.75 (0.53, 1.06) | 0.107 |
| Intention-to-quit = Yes | 4.00 (3.01, 5.33) | < 0.001 | 3.37 (2.49, 4.55) | < 0.001* |
| FTCD | 0.91 (0.86, 0.96) | 0.001 | 0.92 (0.86, 0.99) | 0.018* |
| CES Satisfaction | 1.01 (0.94, 1.09) | 0.750 | ||
| CES Psychological reward | 0.98 (0.88, 1.09) | 0.704 | ||
| CES Aversion | 1.01 (0.86, 1.20) | 0.865 | ||
| PHRS Average | 1.08 (1.03, 1.12) | 0.001 | 1.05 (1.00, 1.10) | 0.063 |
| MNWS | 1.01 (0.99, 1.04) | 0.344 | ||
| QSU Factor 1 | 0.98 (0.96, 0.99) | 0.003 | 1.01 (0.98, 1.03) | 0.683 |
| QSU Factor 2 | 0.96 (0.94, 0.99) | 0.002 | 0.99 (0.95, 1.03) | 0.548 |
| Participants randomized to the gradual and immediate reduction conditions | ||||
| Covariate | Unadjusted Analyses | Adjusted Analyses* | ||
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Treatment = Immediate## | 1.04 (0.77, 1.39) | 0.809 | ||
| VLNC Adherence = Yes | 1.69 (1.25, 2.28) | 0.001 | 1.33 (0.95, 1.88) | 0.099 |
| Age = 18–24 | 0.66 (0.24, 0.88) | 0.021 | 0.51 (0.24, 1.06) | 0.073 |
| Gender = Male | 0.43 (0.31, 0.58) | < 0.001 | 0.52 (0.37, 0.73) | < 0.001* |
| Race = Non-white | 0.81 (0.60, 1.10) | 0.178 | 0.99 (0.65, 1.51) | 0.962 |
| Education = HS or less | 0.76 (0.56, 1.03) | 0.075 | 1.01 (0.71, 1.43) | 0.953 |
| Menthol = Yes | 0.78 (0.58, 1.05) | 0.105 | 0.85 (0.57, 1.26) | 0.411 |
| Intention-to-quit = Yes | 3.72 (2.69, 5.14) | < 0.001 | 3.08 (2.19, 4.34) | < 0.001* |
| FTCD | 0.92 (0.86, 0.97) | 0.004 | 0.94 (0.87, 1.01) | 0.091 |
| CES Satisfaction | 1.06 (0.97, 1.16) | 0.204 | ||
| CES Psychological Reward | 1.03 (0.91, 1.17) | 0.591 | ||
| CES Aversion | 1.00 (0.83, 1.22) | 0.960 | ||
| PHRS Average | 1.06 (1.01, 1.11) | 0.019 | 1.03 (0.97, 1.08) | 0.376 |
| MNWS | 1.02 (0.99, 1.04) | 0.288 | ||
| QSU Factor 1 | 0.97 (0.96, 0.99) | 0.005 | 1.00 (0.97, 1.03) | 0.859 |
| QSU Factor 2 | 0.96 (0.93, 0.99) | 0.015 | 1.00 (0.95, 1.05) | 0.998 |
Logistic regression analyses measuring associations between covariates and support for cigarette nicotine reduction after 20 weeks in the trial.
Adjusted analyses include covariates significant at the p < 0.2 level in the unadjusted analyses;
Immediate vs. gradual reduction; HS = high school; FTCD = Fagerström Test for Cigarette Dependence; CES = Cigarette Evaluation Scale; PHRS = Perceived Health Risk Scale; MNWS = Minnesota Nicotine Withdrawal Scale; QSU= Questionnaire on Smoking Urges; VLNC cigarette adherence was defined as urinary total nicotine equivalents levels ≤ 6.41 nmol/ml at Week 2020
Represents significant findings for the adjusted analyses at the p <0.05 level.