Table 2.
| Univariate Cox | Multivariate Cox | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Beta blocker use (yes vs. no) | 0.58 | 0.33-0.99 | 0.046 | 0.48 | 0.23-1.01 | 0.054 |
| Age (continuous) | 0.99 | 0.97-1.01 | 0.360 | 0.98 | 0.98-1.02 | 0.195 |
| Sex (male vs. female) | 1.09 | 0.68-1.74 | 0.715 | 0.96 | 0.49-1.88 | 0.895 |
| BMI (continuous) | 0.96 | 0.92-0.99 | 0.027 | 0.97 | 0.93-1.02 | 0.263 |
| Smoking (former or current vs. never) | 0.94 | 0.54-1.64 | 0.833 | 0.85 | 0.39-1.82 | 0.670 |
| ECOG performance status (0/1 vs. 2/3) | 0.95 | 0.57-1.61 | 0.861 | 0.85 | 0.38-1.87 | 0.683 |
| CNS metastasis (yes vs. no) | 0.99 | 0.60-1.61 | 0.958 | 1.03 | 0.51-2.10 | 0.926 |
| Tumor PD-L1 status (positive vs. negative) | 0.45 | 0.23-0.87 | 0.017 | 0.57 | 0.26-1.26 | 0.166 |
| Line of treatment (1st vs. 2nd or higher) | 0.33 | 0.19-0.58 | <0.001 | 0.33 | 0.13-0.87 | 0.025 |
| Concurrent chemotherapy (yes vs. no) | 0.42 | 0.15-1.15 | 0.092 | 0.40 | 0.08-2.04 | 0.270 |