Young (8-10 week old) and old (4-5 months old) gp120tg+ and gp120tg− mice were euthanized at 12 weeks post-LP-BM5 treatment (5xl04 pfu, ip.). RNA expression of iNOS (A-C), TNFα (D-F), and IL-12p40 (G-I) in the hippocampus (A, D and G), frontal lobe (B, E, and H), and striatum (C, F, and I) are shown in interactive plots. Data are presented as mean± SEM; n=7-16/group. Two-way ANOVA followed by Tukey post hoc test were performed. * indicates the main effect of LP-BM5 (p<0.05). # p<0.05 between the indicated groups regardless of LP-BM5 treatment. $ p<0.05 between indicated groups under LP-BM5 treatment condition only. & p<0.05 between LP-BM5 treated vs. non treated mice of the indicated group.