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. Author manuscript; available in PMC: 2022 Jan 30.
Published in final edited form as: Toxicology. 2020 Dec 8;448:152651. doi: 10.1016/j.tox.2020.152651

Figure 5.

Figure 5.

Pharmacokinetic parameters for tested drugs. (A) Fraction unbound for each drug was determined using rapid equilibrium dialysis method and is shown for the physiological saline (Control) of cell-specific culture media (for primary hepatocytes or iCell hepatocytes 2.0). Each drug was tested at 1 μM (black bars) and 10 μM (white bars). (B) The amount of drug recovered from either monolayer culture (circles) or perfusate through LAMPS chips (squares) seeded with primary hepatocytes (filled symbols) or iCell hepatocytes 2.0 (open symbols) and cultured for up to 10 days. Data shown are mean±SEM (n=3–9 per condition) and were normalized to starting concentration (red dotted line=100%).