Cartoon description showing the individual subunits of the SAGA complex with their functional domains highlighted. The distinct lobes containing various SAGA subunits are grouped together with subunits that connect the various lobes together intersecting. HEAT = Huntington, Elongation Factor 3, PR65/A, TOR; FAT = FRAP, ATM and TRRAP; FRB = FKBP12-rapamycin binding domain; TIR = Tra1-interacting; SEP = SEP domain; HF = histone fold domain; LisH = lis homology domain; BRD = bromodomain; WD40 = WD domain, G-beta repeat; ZF = Zinc Finger; SWIRM = SWIRM domain; HAT = histone acetyltransferase; Tudor = Tudor domain; ZZ = Zinc finger, ZZ type. Figure design is adapted from Papai et al. [21].