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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Nat Rev Mol Cell Biol. 2020 Jul 6;22(3):183–195. doi: 10.1038/s41580-020-0264-6

Figure 2: Tuning condensate properties through RNA modifications.

Figure 2:

(A) RNA modifications are recognized by ‘reader’ proteins. Interaction with a reader can enhance or inhibit RNA undergoing liquid–liquid phase separation (LLPS). (B and C) RNA modifications can tune RNA structure by blocking or promoting RNA–RNA interactions in cis, within the same RNA molecule (B) or in trans between different RNA molecules(C). Modification of RNA sequence and structure could alter phase separation of target RNA.