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. 2020 Dec 23;14:598435. doi: 10.3389/fnhum.2020.598435

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Copyright © 2020 Sharma, Nenert, Mueller, Maudsley, Younger and Szaflarski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Selected axial slices showing raw metabolite and brain temperature maps derived from a single participant's volumetric magnetic resonance spectroscopic imaging data (MRSI) data. Shown are (A) normalized gray matter volumes, (B) water reference signal, (C) total creatine (creatine + phosphocreatine), (D) total choline, (E) NAA (N-acetylaspartate), (F) myo-inositol, (G) Glx (combined signal from glutamine and glutamate), (H) frequency difference between water and creatine (Δ_H20−CRE), (I) brain temperature calculated according to the equation T_CRE = −102.61(Δ_H20−CRE) + 206.1°C. Raw MRSI data were visualized within the Metabolite Imaging and Data Analysis System (MIDAS) software package, and the figure was created using BioRender.