Figure 3.

Graphical illustration of mean brain temperature for time1 (mean 37.0°C) and time2 (37.4°C) across 47 regions of interest (ROIs) delineated by the modified Automated Anatomical Labeling (AAL) atlas. Brain temperature was non-invasively derived from volumetric magnetic resonance spectroscopic imaging (MRSI) data, using the following equation: T_CRE = −102.61(Δ_H20−CRE) + 206.1°C, where Δ_H20−CRE = chemical shift difference between the creatine and water resonances. For each brain region, colored bars (time1, teal; time2, burgundy), reflect the mean T_CRE; whiskers indicate range of T_CRE values beyond the mean. The mean global brain temperature over all subjects was 37.2°C with spatial variations across regions (37.57–41.49°C). There was a significant main effect for time [F_{(1, 1,591)} = 37.0, p < 0.0001] and for brain region [F_{(46, 1,591)} = 2.66, p < 0.0001]. The time*brain region interaction was not significant [F_(46,1,591) =0.80, p = 0.83].