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. 2020 Dec 23;14:598435. doi: 10.3389/fnhum.2020.598435

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Copyright © 2020 Sharma, Nenert, Mueller, Maudsley, Younger and Szaflarski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mean brain temperature for 47 brain regions delineated by the Automated Anatomical Labeling (AAL) atlas, with estimates of the upper and lower bounds of Minimal Detectable Change (MDC) at which temperatures may be above- or below-typical, respectively. Brain temperature was non-invasively derived from volumetric magnetic resonance spectroscopic imaging (MRSI) data. Voxel-level brain temperature was calculated according to the following equation: T_CRE = −102.61(Δ_H20−CRE) + 206.1°C, where Δ_H20−CRE = chemical shift difference between the creatine and water resonances. The upper bounds of MDC are indicated in dark gray bands, and the lower bounds of MDC are indicated in light gray bands.