Table 2.

Mean MRSI-based brain temperature (T_CRE) in 47 ROIs for both time points time1 (T₁) and time2 (T₂), their standard deviations (SD), and corresponding reproducibility and reliability statistics.

ROI	Scan	n	Mean	SD	COVrep (%)	SEM	MDC
L Calcarine	T1	18	37.320	1.019	1.85	1.131	1.600
	T2	18	37.289	1.244
R Calcarine	T1	18	37.306	1.052	2.24	1.288	1.822
	T2	18	37.247	1.421
L Caudate	T1	18	36.788	0.963	1.66	0.733	1.036
	T2	18	37.106	0.807
R Caudate	T1	18	36.921	0.800	1.73	0.827	1.170
	T2	18	36.922	0.721
Cerebellum	T1	18	36.822	0.848	2.10	1.141	1.614
	T2	18	37.497	1.436
L Anterior Cingulum	T1	17	36.853	0.807	1.29	0.581	0.822
	T2	17	36.641	0.606
R Anterior Cingulum	T1	17	36.965	0.799	1.11	0.511	0.722
	T2	17	36.806	0.610
L Mid Cingulum	T1	18	37.345	0.597	0.81	0.365	0.516
	T2	18	37.512	0.383
R Mid Cingulum	T1	18	37.387	0.661	0.88	0.421	0.595
	T2	18	37.600	0.391
L Posterior Cingulum	T1	18	37.363	0.735	1.41	0.824	1.165
	T2	18	37.262	0.875
R Posterior Cingulum	T1	18	37.364	0.605	1.36	0.696	0.985
	T2	18	37.366	0.698
L Cuneus	T1	18	37.062	1.257	2.50	1.522	2.153
	T2	18	38.140	1.835
R Cuneus	T1	18	37.161	1.316	2.65	1.586	2.243
	T2	18	38.138	1.620
L Frontal Lobe	T1	18	37.431	1.787	2.88	2.713	3.837
	T2	18	37.884	2.582
R Frontal Lobe	T1	17	37.445	1.759	2.56	2.395	3.387
	T2	17	37.771	2.285
L Fusiform Gyrus	T1	18	36.909	1.065	1.60	0.831	1.176
	T2	18	37.221	0.959
R Fusiform Gyrus	T1	18	36.601	1.108	3.08	2.179	3.082
	T2	18	38.067	2.735
L Hippocampus	T1	18	36.758	0.616	1.55	0.879	1.243
	T2	18	36.674	0.902
R Hippocampus	T1	18	36.278	0.956	2.13	1.016	1.437
	T2	18	36.824	0.980
L Insula	T1	18	36.854	0.996	1.92	1.022	1.446
	T2	18	37.126	0.978
R Insula	T1	18	36.572	0.991	1.93	0.934	1.321
	T2	18	36.979	0.897
L Lingual Gyrus	T1	18	37.213	1.134	1.89	1.111	1.572
	T2	18	37.120	1.161
R Lingual Gyrus	T1	18	37.096	1.021	1.61	0.853	1.206
	T2	18	37.355	0.594
L Occipital Lobe	T1	18	37.326	1.761	1.33	0.731	1.033
	T2	18	37.696	2.106
R Occipital Lobe	T1	18	37.179	0.879	2.98	2.507	3.546
	T2	18	38.484	3.504
L Pallidum	T1	18	36.749	1.776	2.58	1.195	1.691
	T2	18	36.693	1.005
R Pallidum	T1	17	36.406	1.381	2.70	1.292	1.828
	T2	17	36.483	0.939
L Paracentral Lobule	T1	18	37.124	1.151	1.49	0.663	0.937
	T2	18	37.603	0.692
R Paracentral Lobule	T1	18	37.409	1.073	1.66	1.430	2.023
	T2	18	37.761	1.190
L Parietal Lobe	T1	18	36.921	1.349	2.57	2.564	3.627
	T2	18	37.877	2.485
R Parietal Lobe	T1	18	36.998	1.424	2.47	2.414	3.414
	T2	18	38.016	2.307
L Postcentral Gyrus	T1	18	36.994	1.232	2.35	2.420	3.422
	T2	18	37.851	2.350
R Postcentral Gyrus	T1	18	37.084	1.157	1.88	2.003	2.833
	T2	18	37.850	1.944
L Precentral Gyrus	T1	18	36.984	1.315	2.57	2.609	3.690
	T2	18	37.891	2.625
R Precentral Gyrus	T1	18	37.028	1.459	2.40	2.216	3.133
	T2	18	37.793	2.211
L Precuneus	T1	18	37.399	0.867	1.69	1.222	1.728
	T2	18	37.920	1.134
R Precuneus	T1	18	37.382	1.002	1.73	1.341	1.897
	T2	18	37.944	1.201
L Putamen	T1	18	36.392	1.105	2.18	1.029	1.455
	T2	18	36.808	0.911
R Putamen	T1	18	36.248	0.975	1.89	0.872	1.233
	T2	18	36.511	0.849
L Rolandic Operculum	T1	18	37.013	0.821	1.76	1.289	1.823
	T2	18	37.419	1.328
R Rolandic Operculum	T1	18	36.983	0.830	1.51	0.757	1.071
	T2	18	37.360	0.582
L Supplemental Motor Area	T1	18	37.187	0.872	1.66	1.301	1.840
	T2	18	37.547	1.190
R Supplemental Motor Area	T1	17	37.251	0.837	1.67	1.295	1.831
	T2	17	37.496	1.142
L Temporal Lobe	T1	18	36.971	0.569	1.24	1.111	1.571
	T2	18	37.308	1.981
R Temporal Lobe	T1	18	36.634	0.822	1.72	1.197	1.694
	T2	18	37.182	1.529
L Thalamus	T1	18	36.823	0.696	1.57	0.853	1.207
	T2	18	36.748	1.059
R Thalamus	T1	18	36.715	0.886	1.94	1.004	1.420
	T2	18	36.824	1.104

For each ROI, reproducibility was measured with the coefficient of variation for repeated measures (COVrep). The standard error of measurement (SEM) provided a measure of reliability. Minimal Detectable Change (MDC) was calculated from SEM to provide a clinically meaningful basis for evaluating T_CRE changes over repeated measures.

MRSI, magnetic resonance spectroscopic imaging; ROI, region of interest; n, number of observations; R, right; L, left.