Table 1.
Categories of drugs under Investigation for COVID19 Treatment or Prevention (2,145 interventional studies registered on ClinicalTrials.gov as of October 31, 2020).
| Category | Studies | Drugs | PubMed | Published clinical trials | Phases of studies | Status of studies | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1/2 | 2 | 2/3 | 3 | 4 | Others | Active, not recruiting | Not yet recruiting | Recruiting* | Completed | Suspended | Terminated/ withdrawn | |||||
| Antimalarials | 196 | 8 | 1,917 | 27 | 10 | 3 | 52 | 26 | 69 | 21 | 15 | 15 | 39 | 85 | 21 | 11 | 30 |
| Anti-inflammatory | 141 | 24 | 1,399 | 8 | 10 | 2 | 33 | 25 | 45 | 12 | 14 | 13 | 30 | 83 | 17 | 2 | 4 |
| Immune-modulators | 138 | 4 | 1,320 | 5 | 20 | 9 | 51 | 13 | 17 | 2 | 26 | 9 | 18 | 85 | 16 | 0 | 2 |
| Antivirals | 122 | 27 | 869 | 27 | 3 | 3 | 56 | 17 | 30 | 5 | 8 | 10 | 30 | 81 | 9 | 5 | 6 |
| Plasma Infusion | 117 | 39 | 857 | 11 | 4 | 0 | 56 | 16 | 29 | 6 | 6 | 15 | 28 | 80 | 10 | 5 | 5 |
| Antibiotics | 83 | 25 | 615 | 8 | 4 | 3 | 20 | 3 | 21 | 7 | 25 | 3 | 26 | 81 | 5 | 1 | 5 |
| Stem cell therapies | 75 | 6 | 550 | 5 | 4 | 1 | 24 | 7 | 29 | 4 | 6 | 5 | 18 | 81 | 6 | 8 | 8 |
| Dietary/vitamins | 71 | 14 | 4,097 | 3 | 17 | 16 | 5 | 2 | 24 | 6 | 1 | 13 | 13 | 83 | 1 | 0 | 0 |
| Others | 70 | 17 | 543 | 93 | 21 | 21 | 17 | 1 | 2 | 1 | 7 | 7 | 18 | 82 | 5 | 0 | 1 |
| Antiparasitic | 66 | 5 | 114 | 1 | 1 | 2 | 23 | 13 | 15 | 4 | 8 | 2 | 23 | 81 | 8 | 0 | 0 |
| Antibodies | 64 | 19 | 608 | 4 | 2 | 2 | 13 | 7 | 21 | 13 | 6 | 2 | 19 | 82 | 1 | 0 | 2 |
| Anticoagulant | 55 | 31 | 5,388 | 4 | 4 | 8 | 20 | 2 | 9 | 7 | 5 | 5 | 11 | 81 | 2 | 1 | 1 |
| Steroids | 51 | 7 | 761 | 9 | 0 | 1 | 13 | 6 | 15 | 9 | 7 | 2 | 10 | 80 | 6 | 1 | 4 |
| Cardiovascular/antihypertensive | 49 | 25 | 648 | 1 | 1 | 1 | 26 | 10 | 8 | 2 | 1 | 7 | 10 | 80 | 4 | 2 | 2 |
| Vaccines | 43 | 15 | 182 | 14 | 2 | 3 | 19 | 6 | 6 | 4 | 3 | 2 | 6 | 80 | 2 | 1 | 4 |
| Targeted therapies | 40 | 7 | 119 | 3 | 3 | 4 | 20 | 3 | 8 | 1 | 1 | 5 | 14 | 80 | 0 | 0 | 1 |
| Cytokines | 32 | 5 | 706 | 17 | 2 | 1 | 15 | 1 | 6 | 5 | 2 | 2 | 8 | 83 | 5 | 1 | 0 |
| ACE receptor targeted | 24 | 11 | 789 | 1 | 3 | 0 | 8 | 3 | 3 | 5 | 2 | 0 | 8 | 81 | 2 | 1 | 1 |
| Neurologic/anesthetic | 21 | 13 | 116 | 3 | 2 | 0 | 7 | 2 | 3 | 3 | 4 | 3 | 8 | 80 | 0 | 0 | 1 |
| Hormonal (other than steroids) | 20 | 12 | 1,095 | 12 | 3 | 1 | 8 | 2 | 4 | 2 | 0 | 2 | 6 | 80 | 0 | 0 | 1 |
| Traditional/herbal | 13 | 9 | 746 | 10 | 0 | 2 | 2 | 5 | 2 | 0 | 2 | 0 | 2 | 80 | 1 | 2 | 0 |
Data extracted from ClinicalTrials.gov on October 31, 2020; PubMed search (October 31, 2020) shows hits of drugs in each category in combinations with the following search world (COVID OR COVID-19 OR COVID19 OR SARS-COV-2 OR SARS-COV2); Rows may not add up to the expected total due to some missing or unknown (e.g., status “No longer available” or “Active Not Recruiting”). Columns may not add up to the expected total number due to the overlap in some drugs (e.g., targeted therapies and antibodies) and inability to categorize some studies (e.g., studies of medical devices).
Recruiting studies include studies recruiting by invitation.