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. 2020 Dec 23;11:600989. doi: 10.3389/fmicb.2020.600989

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Copyright © 2020 Wang, Xu, Wang, Pan, Zhang, Han, Huang, Wu, Yang, Yang, Yang, Shu, Zou, Li, Luo, Yao, Wang, Qiu, Wang, Zhang, Yao, Yan, Zhou and Shang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Production of TNF-α in tissues from patients with coronavirus disease-2019 (COVID-19). (A) Imaging mass cytometry (IMC) for TNF-α in the lungs, intestine, liver, kidneys, and spleen from controls or patients with COVID-19; iridium-DNA staining is shown in blue, and TNF-α staining is shown in red. (B) Bar plot for the comparison of TNF-α in the lungs and intestine of controls and three patients with COVID-19. The significance of differences between groups is shown as horizontal brackets and was assessed using Fisher's exact test. ***P < 0.01; ns, P > 0.01.