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. 2020 Dec 23;11:615536. doi: 10.3389/fimmu.2020.615536

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Copyright © 2020 Zhang, Zhang, Liu, Lan, Sun, Mai and Wan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SCFAs augmented HIF-1α expression, lysozyme activity and bacterial killing of HKMs via HDAC Inhibition. (A–D) HKMs were treated with NaB (10 mM) or TSA (1 μM). After 24 h, the bacterial survival rate in HKMs (A, n = 10), the gene expression of HIF-1α (B, n = 8) or lysozyme (C, n = 7), and lysozyme activity (D, n = 4) were analyzed. (E) HKMs were treated with control buffer, NaB (1 mM), pertussis toxin (PT, 1 μg/ml) or NaB plus PT for 24 h, and the gene expression of HIF-1α in HKMs was assessed (n = 14). The results were calculated from at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ns: non significance.