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. 2020 Dec 23;8:605744. doi: 10.3389/fcell.2020.605744

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Copyright © 2020 Zhang, Zhao, Li, Fu, Zhang, Fu, Zheng and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Promoter methylation and genetic alterations of HHEX and potential regulatory mechanism of HHEX in regulating breast cancer (BC). (A) Promoter methylation and genetic alterations of HHEX in BC patients. (a) Promoter methylation levels of HHEX in BC determined using UALCAN. (b) Relationship between nodal metastasis status of BC with the promoter methylation of HHEX determined using UALCAN. (c) OS for HHEX alterations was analyzed using cBioportal. (B) Genetic alterations of HHEX in BC patients determined using cBioportal. (C) Venn of the DEGs related to BC stem cells and the DEGs after HHEX changed. (D) KEGG pathway enrichment of the 15 common genes. (E) The neighbor gene network of 15 genes was constructed using STRING. ***P < 0.001.