Table 1.
Summary of databases used in this study.
| Name | Link | This study | Keywords |
|---|---|---|---|
| Oncomine | https://www.oncomine.org/resource/main.html | To analyze the HHEX mRNA expression in different cancers | Gene expression |
| UALCAN | http://ualcan.path.uab.edu/ | To analyze the HHEX mRNA expression in different molecular subtypes of BC patients | Gene expression; 16 cancer types; survival curve; DNA methylation |
| GEPIA | http://gepia.cancer-pku.cn/detail.php | To assess the correlations between genes | Gene expression; survival curve; isoform details; genes correlation; similar genes detection |
| TCGAportal | http://www.tcgaportal.org | To investigate the expression and survival of HHEX in human tissues | Gene expression; 28 cancer types; survival curve; DNA methylation; mutation |
| Human Protein Atlas | https://www.proteinatlas.org/ | To detect HHEX protein expression and survival | Proteins distribution; subcellular localization; impact for survival |
| Kaplan-Meier Plotter | http://kmplot.com/analysis/index.php?p=background | To analyzed the correlations between genes and miRNAs expression and RFS as well as OS | Breast cancer; subtype; survival curve |
| OncoLnc | https://www.oncolnc.org/ | To detect HHEX survival | Breast cancer; survival curve |
| PROGgeneV2 | http://genomics.jefferson.edu/proggene/ | Gene expression; breast cancer; subtype; survival curve | |
| bc-GenExMiner | http://bcgenex.centregauducheau.fr/BC-GEM/GEM-Accueil.php?js=1 | To compute breast cancer gene-expression correlation analyses, for gene prognostic analyses | Gene-expression correlation; gene prognostic analyses |
| cBioportal | http://www.cbioportal.org/ | To detect HHEX genetic alterations | Genetic alterations; survival curve |
| GEO | https://www.ncbi.nlm.nih.gov/geo/ | To selected data sets related to breast cancer stem cells to explore further mechanisms | Gene expression; datasets details |
| STRING | https://string-db.org/cgi/input.pl | To obtain the interaction network between HHEX and other important proteins | Protein details; interactive network; functional enrichment |
| starBase v3.0 | http://starbase.sysu.edu.cn/index.php | To predict the miRNAs related to HHEX; To perform miRNAs as well as correlation analysis between miRNAs and HHEX mRNA | miRNA target; Pan-cancer |